I have been doing a lot of research on the MTHFR gene polymorphism. Apparently around 35% of the population has this genetic mutation. Those that have this gene problem cannot convert synthetic folic acid (which is in everything!) into the active form --L 5 methyl-tetrahydrofolate. People that have this gene polymorphism don't clear heavy metals well. They have an increased risk of cancer (especially breast, colon, and gastric), and have a susceptibility to addiction. Around 98% of children with Autism Spectrum Disorder have at least one of the MTHFR gene mutations.
The following conditions are associated with the MTHFR gene polymorphism: cardiovascular disease, stroke, peripheral neuropathy, still births, pre-eclampsia, neural tube defects/cleft lip, depression, anxiety, IBS, fibromyalgia, chronic fatigue, dementia, migraines, schizophrenia, parkinson's, miscarriage, and infertility.
The biggest problem with this gene mutation is the inability to detoxify heavy metals. Symptoms of heavy metal overload include: social deficits, withdrawal, OCD, bi-polar disorder, schizophrenia, aggression, tantrums, fibromyalgia, colon/pancreatic cancer, liver/kidney problems, hair loss, premature graying, rashes, poor concentration, etc...
Here are some excellent resources for further reading:
MTHFR treatment
MTHFR related health problems
Mark Hyman article on Folic Acid
Video lecture on MTHFR by Neil Rawlins, MD
List of MTHFR resources (also from Neil Rawlins, MD)
Dangers of folic acid supplementations (by Dr. Fuhrman)
Pub Med Studies on:
autism, autism, autism, psychiatric disorders, breast cancer,
A slide show from Kenneth Bock, M.D. on Autism/ADHD/Allergies/Asthma:
HERE
Oh, and the active form of folate is available online and in specialty pharmacies, but it is hard to find. There are several prescriptions with active forms of the B vitamins, such as Meta NX, Deplin (folate for depression), and Cerefolin (often prescribed for alzheimers and fibromyalgia). There is a prescription prenatal vitamin with methylfolate called Neevo.
Here is a Mothering.com discussion about real folate.
Here is an article linking folate blood levels to IgE allergies. Of course.
I was happy to find your blog! I have suffered from poor health all my life - endometriosis (which led to hysterectomy), and interstitial cystitis, chronic inflamation around my heart, joint pain - some lupus tests possitive (lupus anticoagulant, ana), and have several chronic infections, fibromyalgia, migrains ... they did blood clotting tests and I had a lot of micro clotts in my blood .. so they tested the genetics and I have a homozygous mutation of the c6777T MTHFR gene. I also have a brother with autism and a sister with frequent miscarriages who tested possitive for the lupus anticoagulant. I wonder if you have any interesting info about if MTHFR can cause these kinds of problems? I'm just very new to all this and trying to understand as best I can.
ReplyDeleteYes! Mthfr can cause all of those problems. Mthfr has been linked to blood clots, fibromyalgia, migraines, autism and miscarriages. It also has a strong link to autoimmune diseases like lupus. My mom has fibro, and had to have a hysterectomy very young due to severe endometriosis. She also has interstitial cystitis.
DeleteThis comment has been removed by the author.
DeleteI am so glad you have this blog. I am c677t /a1298c. I have always had weird medical symptoms. I had taken CIPRO three times over 1 1/2 hrs and had multiple sensory issues, a thermograhm showed inflammation everywhere except my heart and lungs with multiple organ problems, especially the colon. I ended up with diareah for 11 weeks, and lymphocytic colitis, and major disbiosis in gut flora with parasites. I basically became like an autistic person who advised social contact, wore ear plugs, advised bright light(borderline close angle glaucoma), smell drove me to almost vomit or gave me a migrane, my tastes changed drastically, I had trouble swallowing food, and even liquid, my sensorimotor went haywire(I thought my car frame was misaligned because it was rattling. The whole car), had fibromyalgia, and ended up with arthritis in both my hands. I went month without being able to sleep, only sleeping on and off for forty five minutesn to an hour and a half at a time but hardly at all between 11:30 to 4:30. The main thing is to fix your gut flora first with probiotics, enzymes to eat the years, avoid sugar, folate, Methyl B-12, Calcium citrate, magnesium, zinc, molybdenum, P5P. I got great vitamins and supplements and advise from AutismCoach.
ReplyDeleteI must reply in case you are unaware of the Dangers of Fluoroquinolone Drugs which Cipro & Levaquin amongst many others. They r not strictly antibiotics as we typically think of them. In fact they are CHEMO-THERAPEUTIC ANTI-BIOTICS. THEY DO NOT DISTINGUISH BETWEEN OUR DNA AND THE BACTERIA'S DNA.
DeleteI was severely injured by this class of drugs. I amongst tens of thousands have been harmed. There is much information on the web about the horrors of these drugs. Law suits, Class Action Law Suits. PBS NEWS HOUR did a report about this July 16th, 2011 . Titled "CERTAIN ANTIBIOTICS SPUR WIDENING REPORTS OF SEVERE SIDE EFFECTS.
Tragic for the public this has been going on for 20 years. The full complete dangers are not disclosed to the Medical Community & therefore the Public. The adverse reactions are often delayed by weeks, with continuing systemic manifestations occurring for months. This is appallingly not a rarity. Once you have been injured and do your own research the curtain is pulled back revealing a massive amount of people hurt. Some have been told they have MS,.....when in fact the repeated exposure to this Class of Drugs has savaged every organ and system of their body.
I myself after 2years of painful & slow recovery....endless research have now taken a great interest in the science and research happening within the world of Autism. I have not had any genetic testing, but have recently benefitted from using Methylcobalamin for the Cipro induced Peripheral Neuropathy.
Hi Ava, I have a mutated MTHFR gene also, and came across this site looking for some answers. I have family history of diabetes also. Incase you haven't come across information about Alpha Lipoic Acid - this can cure diabetic Neuropathy!!! Maybe it can help you as well. Take 300 milligrams 2 times a day. If you take it with Vitamin C - this will help the Alpha Lipoic Acid to work better. Hope this works for you.
DeleteWow, ALPHA LIPOIC ACID IS A HEAVY METAL CHELATOR!!
DeleteNever take this as a anti-oxident if you have amalgams. It moves metals. I did that!!! I'm paying for it everyday. Please don't.
I've just started taking the ALA and I do have amalgams. What symptoms do I need to watch for? I'm taking it for neuropathy and I have Fibro.
DeleteMy ex-wife has the MTHFR gene and we did not find out till she had 2 miscarriages. For her to hold my youngest son she had to inject heparin daily. She had early contractions at 29 weeks but with help from magnesium and a few other drugs he was born at 35 weeks.
ReplyDeleteI do have a question about the MTHFR gene. Does this gene cause HPV? Before we started to have children she was found to have HPV by her OB and we had been high school sweethearts with no other unprotected meetings with other people. I have never had a HPV outbreak but I am single and ready to get back to the dating scene.
Please feel free to email me at s02j26k75@gmail.com as I do not know if I will find this blog again.
We just found out yesterday that our 19 year old daughter who has had increasing health problems (pretty much every symptom of both fibromyalgia, chronic fatigue and MORE) has MTHFR both C677T and A1298C mutations. I can hardly believe we have actually found a REASON for all these years of worsening physical problems! I've read lots and lots about it already, and one interesting thing I've noted is that some folks are treating with just folic acid and B vitamins. From what I gather, this is NOT the right cure, but one needs to take methylated folate (methylfolate) which is a different thing.
ReplyDeleteI am looking forward to learning more and to HOPEFULLY seeing some remarkable changes in my daughter's health. For years we have pursued every imaginable alternative health option/diet/supplements/etc. and all to no avail. I am almost afraid to get my hopes up that this will help heal her, but am optimistic!!
:)
evy
Hey Evy,
ReplyDeleteDid you see progress with treatment?
I had similar symptoms, including the mutation as well and have tested positive for lyne disease and co-infections.
Has your daughter been tested?
I'd love to exchange more information,
Please email me at louispoletti@gmail.com
Thanks for asking, that's very kind of you. So far there is not much improvement :( We are thankful for some 'brain' changes we've seen but so far no physical alleviation of symptoms. Likely because the MTHFR is but one of the pieces in the VERY complicated puzzle? Discouraging, but we'll keep plugging along. She says that the Thorne brand mthf gives her a stomach ache while the metabolic maintenance does not. Odd how so many of the supplements have the very things that our poor MTHFR folks are terribly sensitive or allergic to! Hmph! Anyway, I did email you and look forward to hearing back from you.
ReplyDelete:)
evy
Evy,
ReplyDeleteI strongly recommend you look into Dr Amy Yasko's web presence on treating MTHFR mutations in children with autism aswell as other genetic mutations linked to that pathway - like the CBS gene, which can create excess ammonia /sulfur to build up in the body - so avoiding high ammonia/sulfur foods like cabbage, broccoli, tomatoes, meat etc is essential aswell as treating the MTHFR imbalances.
I'm an adult with chronic health conditions and have finally after 17 yrs research got genetic results showing several mutations within the methylation pathway, transulfation cycle, coupled with MTHFR homozygous.
Pheonix rising forum and Dr amy yasko are great places to learn more
Continued improved health to all :-)
Bec
Bec, thanks so much for taking the time to comment. Yes, I am learning much on all of this. The Phoenix Rising site has soooooooooooooo much info.
ReplyDeleteThanks again!
evy
I have just been diagnosed with a single A1298C mutation of MTHFR. My doctor is trying to figure out what supplements to prescribe. I have hemochromatosis and she does not want to prescribe anything that will interact negatively.
ReplyDeleteCan anyone share the symptoms of having MTHFR? I had miscarriages and wonder if I have MTHFR or blood clotting issue...
ReplyDeleteIt certainly can be a cause of increased miscarriages. Other causes can be B12 deficiency, which may be a result of MTHFR or other methylation deficiencies and/or vitamin D deficiency. GO get yourself checked. Your vitamin B12 level should be above 300 (not 190 as the path labs say) and your vitamin D should be at 100 or above. You need to also check intracellular folate levels, which are a much better indication than serum folate.
ReplyDeleteDon't know if you are still flowing this blog Evy, but wanted to share this information. I am a compound heterozygote like your daughter. From what I understand from my naturopath, chronic fatigue is more associated with low folate. For me personally, I also have low capacity for processing b12 so need high amounts of that as well even though my serum level is high enough. On top of Pure Encapsulations B Complex Plus, I take 5 mg of 5mTHF and 5 mg of methyl B12 as well as Iron. It is important to look at the cofactors for processing as well as what you are deficient in. Also food allergies and intolerances are common with MTHFR and need to be addressed. Gluten especially can be a culprit in autoimmune diseases. Dr. Ben Lynch and Dr. Nancy Mullan are also good sources of information. Lynch has a really good presentation on his site. Hope this is helpful and hope your daughter is making progress.
ReplyDeleteHi, I read your post and have a question. Me and my kids have the 15Q11.2 deletion, and a FB group for this mentioned that those with the deletion also have the MTHFR. My question is, can the MTFR and an autoimmune make detox much more problematic? I was able to balance my daughter's immune system and she detoxed for 3 days straight (vomiting).
ReplyDeleteWow! I saved this link and was just going thru past emails. So much has changed! We now have the opportunity to really find out the cause. Having Lyme, CFS, fibromyalgia,next.. Hashimoto's, and amalgam poisoning (had them safely removed now) then the genetic testing. My personal body environment is causing my genes to express, well, not so good. But....at least I know. We can help ourselves by chelating, detoxing, eliminating foods,taking supplements, etc..It's difficult at times to stay positive and moving forward with self care. I've been thru the gammit, all pharmaceuticals, in the beginning, now... nutraceuticals. It's been 25+ yrs. I must say it's much better now, no drug side effects causing another drug to be added to the list! Thank you, I've learned so much, from all those, who pledge "to do no harm" I'm grateful. Be well everyone!! Never give up.
ReplyDeleteDr. James herbal medications will cure every inch of your Fibroid, OK. When taken Dr. James herbal mix medicine to cure your Fibroid and any other Infertility, You must not be far from your home, because it will make you visit the restroom often in passing out the Fibroid gradually Thanks to Dr. James herbal mixed medicine for his help in shrinking off my long term uterine fibroid. I had pelvic pain, heavy menses, and swelling. I went to the hospital and was diagnosed with fibroid and advised to go for surgery. I was scared and I went online for more info and remedy for fibroid. Luckily, I found Dr. James's natural medication for fibroid. I reached out to him, and he prepared me with his herbal mix medicine for fibroid shrinking, and I used the medicine as he prescribed for me and my fibroid disappeared totally and is now a year plus since I got cured. His herbal medicine is easy to drink with no side effects.… He also specializes in providing solutions in any of these spiritual gynecology diseases affect human existence such as:
ReplyDelete1 fibroid, asthma, ALL STDs, Urine tract infection
2 weakness of man organ
3 infections of all kinds (yeast infection)
4 blockages from the fallopian tube
5 cysts. From the ovaries
6 unpleasant smell from the vagina
7 irregular menstruation, menopause
8 infertility for easy Conception. 9. HIV/AIDS, GENITAL HERPES VIRUS, ALZHEIMER'S/DEMENTIA.
10.skin diseases, Toilet infection, and bad body odor……. Etc..
11. Watering sperm (low sperm count) is not able to get a woman pregnant.
Simply contact the spiritualist on (drjamesherbalmix@gmail.com) to get his Herbal Medication to cure your diseases and put yourself on a motherhood side of life.
(No more adoption, with DR JAMES your problem will be solved and you will have your child with ease.
Contact Dr. James on his Email at (drjamesherbalmix@gmail.com).your solution home
I have been suffering from a deadly disease (Hsv) for the past 2 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how Dr Ehimare helped someone in curing his (Hsv) herpes disease, quickly I copied his email which is drehimare3@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on Drehimare3@gmail.com Or whatsapp him via +1 (267) 691-1087
ReplyDeleteThe cure for FIBROID without surgery is finally available. Dr. Uduehi has the solution and I’m a testimony to his great work. I had UTERINE FIBROID for years , I took different kinds of medicine and even went through surgery and it came back after some time, until I saw Dr. Uduehi’s recommendation online and I reached out to him and the fibroid shrank totally after the medication. It’s more than a year since I got free no sign of fibroid and am pregnant now for the first time. Doctor’s contact: (+234-708-487-8384) (uduehiherbalcare@gmail.com)
ReplyDeleteHOW I GOT RID OF HERPES SIMPLEX VIRUS BY DR VOODOO
ReplyDeleteI want to inform the public how I was cured of herpes simplex Virus by a herbal Dr called VOODOO. I visited different hospitals but they gave me a list of drugs like Famvir, Zovirax, and Valtrex which are very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedies on Herpes and I saw comments of people talking about how dr VOODOO cured them. I Was scared because I never believed in the Internet but I was convinced to give him a try because I had no hope of being cured of herpes so I decided to contact him on his email, i searched his email on the net and I saw a lot of people testifying about his goodness. When I contacted him he gave me hope and sent a Herbal medicine to me that I took and it seriously worked for me, am a free person now without any problems, my HERPES result came out negative. You can contact him on his what - sapp via +2348140120719 or email voodoospelltemple66@gmail.com and get all your problems solved.